Uji Aktivitas Antidiabetes Ekstrak Etanol Bunga Kertas (Bougainvillea spectabilis Willd.) Pada Tikus Wistar Yang Diinduksi Aloksan

Sabuding, Miss Amanee and , Tanti Azizah Sujono, M.Sc., Apt (2018) Uji Aktivitas Antidiabetes Ekstrak Etanol Bunga Kertas (Bougainvillea spectabilis Willd.) Pada Tikus Wistar Yang Diinduksi Aloksan. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Diabetes mellitus is a world health problem because it can cause mortality and morbidity is relatively very high. Paper flower (Bougainvillea spectabilis Willd.) Is a family of Nyctaginaceae containing D-pinitol has activity to lower blood glucose levels. This research is aimed to test and determine the potential of paper flower ethanol extract on the effect of decreased blood glucose levels of alloxan-induced rats. The method used is the experimental method "pre and post test control group design". This study used 25 mouse-induced rats using aloxan 150 mg/kgBW on ip and given 0.5% glucose solution after alloxan induced, divided into 5 groups of negative control group (CMC-Na 0.5%), positive control ( Metformin 76.5 mg/kgBW), and treatment groups with dose levels of 100, 200 and 400mg/kgBW. Blood sugar levels were measured on the first day, day 0 and day 7. Measurement of blood glucose level using visible spectrophotometer at λ 500 nm. The results showed that the dose ethanol extract of paper flowers 100, 200 and 400 mg/kgBW, had significantly lower activity of blood glucose level compared with the negative control group with the third p value of p <0.000 and was not significant compared with the positive control group with p values for each dose of p <0.181, p <0.722, and p <0.226 respectively.

Item Type:	Karya ilmiah (Skripsi)
Uncontrolled Keywords:	paper flower ethanol extract, antidiabetes, alloxan
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Farmasi
Depositing User:	AMANEE SABUDING
Date Deposited:	07 Feb 2018 04:09
Last Modified:	07 Feb 2018 04:09
URI:	http://eprints.ums.ac.id/id/eprint/59447

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