Sari, Intan Arsyita and , Arifah Sri Wahyuni, M.Sc.,Apt. (2018) Uji Aktivitas Antiinflamasi Ekstrak Etanol Rimpang Lengkuas (Alpinia Galanga) Pada Tikus Putih Jantan Galur Wistar Yang Diinduksi Karagenin. Skripsi thesis, Universitas Muhammadiyah Surakarta.
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Abstract
Inflammation is the body's defense response to physical, chemical and mechanical stimuli. The galangal rhizome (Alpinia galanga) is used as an anti-inflammation empirically. The objective of this research was to determine the antiinflammatory activity of galanga rhizome extract in white male rats wistar strain induced by 1% carragenin. The extraction of galanga rhizome was done by using maceration in ethanol 96%. Zerumbon content in the extract was known by qualitative test with TLC. A total of 12 rats were divided into four groups. Group I (negative control) was treated with 0.5% CMC-Na, group II (positive control) was given with 10 mg/kgBB dose of Diclofenac, and groups III and IV were treated with ethanol extract of galangal rhizome with doses of 200 and 500 mg/kg body weight. The observation was performed for 7 hours with frequency measurement of oedem volume every 30 minutes. Data obtained from udem volume measurements were used to calculate AUC (Area Under the Curve) and percent anti-inflammatory power. The data were then analyzed by Kruskal-Wallis and continued by Moses extreme reaction test. Result showed that 200 and 500 mg/kg body weight of ethanol extract of galangal rhizome has antiinflammatory effect on Wistar strain white male rat 31,22% and 18,49%, respectively.
Item Type: | Karya ilmiah (Skripsi) |
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Uncontrolled Keywords: | antiinflammatory, ethanol extract, galangal rhizome (Alpinia galanga), karagenin |
Subjects: | R Medicine > R Medicine (General) |
Divisions: | Fakultas Farmasi > Farmasi |
Depositing User: | Intan Arsyita Sari |
Date Deposited: | 06 Feb 2018 08:08 |
Last Modified: | 06 Feb 2018 08:08 |
URI: | http://eprints.ums.ac.id/id/eprint/59393 |
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