Widya Aslama, Aulia and -, Prof. Dr. dr. EM Sutrisna, M.Kes (2019) Identifikasi Drug Related Problems (DRPs) Kategori Ketidaktepatan Dosis,Kontraindikasi Dan Interaksi Obat Pada Pasien Kanker Payudara Di Instalasi Rawat Inap Rsud Dr.Moewardi Tahun 2018. Skripsi thesis, Universitas Muhammadiyah Surakarta.
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Abstract
Breast cancer is the most common cancer in the world and ranks number two as the largest cancer contributor to death. In breast cancer therapy patients get more than one type of drug (polypharmacy) this creates an opportunity for unwanted events related to drug therapy (drug related problems). This study aims to determine the presence of DRPs in the category drug selection, category dose selection and drug interactions. The research conducted was a descriptive non-experimental research with retrospective data collection using patient medical record data and the results of the study were analyzed using descriptive methods. Data taken from medical record data of breast cancer patients at Dr. Moewardi Hospital in 2018 and conducted quota sampling with sampling criteria is patients diagnosed with breast cancer, cancer patients who received chemotherapy, patients treated at inpatient installations, patients who have complete medical record data and patients who have laboratory data (SGOT, SGPT, and SCr) if the drug needs dose adjustment. Data were analyzed based on KSM chemotheraphy regimen guidelines in the RSDM medical oncology subdivision, guideline NCCN Breast Cancer Version 3.2018, Drug Information Handbook (DIH) 17th edition, European Medicines Agency, Medscape and Stockley’s Drug Interaction 8th edition. Results from the analysis of 71 patients found that there were 349 cases of drug related problems related to underdose of 127 cases (36.38%), overdose of 14 cases (4.01%) and 208 cases of drug interactions (63.80%). Based on the severity of cases the drug interactions were divided into minor 67 cases (32.20%) and major 141 cases (67.80%). Based on the mechanism of pharmacology, pharmacodynamic interactions 7 cases (3.36%), pharmacokinetic interactions 160 cases (76.92%) and 41 cases (19.71%) unknown mechanism. No drug related problems found related to contraindicated drugs.
| Item Type: | Karya ilmiah (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Breast Cancer, Drug Related Problems, Chemotheraphy |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Farmasi |
| Depositing User: | AULIA WIDYA ASLAMA |
| Date Deposited: | 10 Aug 2019 06:49 |
| Last Modified: | 10 Aug 2019 06:49 |
| URI: | http://eprints.ums.ac.id/id/eprint/75971 |
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