Aktivitas Sitotoksik Ekstrak Etil Asetat Umbi Bawang Putih (Allium Sativum L.) terhadap Sel Kanker MCF-7 Dan T47D

Anwar, Khaeditama Purnama and , Ratna Yuliani, M.Biotech.st. (2019) Aktivitas Sitotoksik Ekstrak Etil Asetat Umbi Bawang Putih (Allium Sativum L.) terhadap Sel Kanker MCF-7 Dan T47D. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Breast cancer is a dangerous disease and the prevalence is quite high in Indonesia. The use of chemotherapy agents has many disadvantages. New solutions are needed to minimize the side effects. One of them is by utilizing herbs such as garlic (Allium sativum L.) which is known to have anticancer activities. The purpose of this study was to determine the cytotoxic activity of ethyl acetate extract of garlic on MCF-7 and T47D cancer cells and identify the compounds in it. Extraction of garlic was done by maceration method, identification of compound in the extract was carried out by thin layer chromatography method, and cytotoxic activity test was carried out by MTT-assay method. The results showed that ethyl acetate extract of garlic have a weak cytotoxic effect on T47D cells with IC50 value of 528,535 μg / mL and did not have cytotoxic effect on MCF-7 cells. TLC showed that the extract contains organosulfur compound allicin with Rf value of 0,25 and sulphide with Rf value of 1.

Item Type: Karya ilmiah (Skripsi)
Uncontrolled Keywords: Allium sativum L, MTT-assay, MCF-7 cell, T47D cell
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: KHAEDITAMA PURNAMA ANWAR
Date Deposited: 11 Feb 2019 08:18
Last Modified: 11 Feb 2019 08:18
URI: http://eprints.ums.ac.id/id/eprint/70906

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