Uji Efektivitas Ekstrak Etanol 70% Biji Coklat (Theobroma cacao L.) Terhadap Peningkatan Kadar Kolesterol HDL (High Density Lipoprotein) Pada Mencit (Mus musculus)

Haryanti, Vesty Anggraini and , Prof. DR. Dr. EM Sutrisna (2018) Uji Efektivitas Ekstrak Etanol 70% Biji Coklat (Theobroma cacao L.) Terhadap Peningkatan Kadar Kolesterol HDL (High Density Lipoprotein) Pada Mencit (Mus musculus). Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Background: Cocoa bean (Theobroma cacao L.) contains flavonoid compounds. Flavonoids can prevent oxidation of LDL cholesterol, inhibit platelet activation and inhibit clot forming which lead to HDL level increase. Objective: To determine the effectiveness of 70% ethanolic extract of cocoa bean (Theobroma cacao L.) on decreasing HDL cholesterol level in mice (Mus musculus). Methods: This research is a laboratory experimental with pre and post test control group design. The subjects were 25 male mice Swiss Webster strain Mus musculus aged 2-3 months, weight 20-30 grams induced with hypercholesterolemic foods and PTU for 7 days. Subjects were divided into 5 groups: negative control group, positive control group (simvastatin 0,0364 mg/20grBW), treatment group 1 (0,196mg/20grBW), treatment group 2 (0,392mg/20grBW), treatment group 3 (combination of cocoa bean extract at dose of 0,392mg/20grBW and simvastatin 0,0182mg/20grBW). Measurements of HDL cholesterol were performed on day 7, day 14, and day 28. Data were analyzed using paired t test and one-way ANOVA followed by post hoc LSD test. Results: The result of one-way ANOVA statistic test, we find that p=0,000 (p<0,05) which shows the significant difference of HDL levels in mice between groups. The results of post hoc LSD test between negative control with treatment 1 p= 0,015, negative control with treatment 2 p= 0,000, negative control with treatment 3 p= 0,000. The results of post hoc LSD test showed p<0,05 which determine significant differences among each group with the negative control group. Conclusion: Cocoa bean (Theobroma cacao L.) extract can increase the HDL level of mice (Mus musculus) with doses I (0,196mg/20grBW), II (0,392mg/20grBW) and combination of cocoa bean extract (Theobroma cacao L.) at dose of 0,392mg/20grBW with simvastatin 0,0182mg/20grBW.

Item Type:	Karya ilmiah (Skripsi)
Uncontrolled Keywords:	Ekstrak Biji Coklat (Theobroma cacao L.), HDL, Flavonoid
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Fakultas Kedokteran > Kedokteran
Depositing User:	VESTY ANGGRAINI HARYANTI
Date Deposited:	12 Feb 2018 08:39
Last Modified:	12 Feb 2018 08:39
URI:	http://eprints.ums.ac.id/id/eprint/60335

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