Uji Efektivitas Ekstrak Etanol 70% Lidah Buaya (Aloe Vera L.) Terhadap Penurunan Kadar LDL Pada Tikus (Rattus Norvegicus) Putih Jantan Hiperkolesterolemia

Primayanti, Yustika Qasthari and , Dr. Devi Usdiana Rosyidah, M. Sc (2018) Uji Efektivitas Ekstrak Etanol 70% Lidah Buaya (Aloe Vera L.) Terhadap Penurunan Kadar LDL Pada Tikus (Rattus Norvegicus) Putih Jantan Hiperkolesterolemia. Skripsi thesis, Universitas Muhammadiyah Surakarta.

	PDF (Halaman Depan) HALAMAN DEPAN.pdf Download (1MB)
	PDF (BAB1) BAB I.pdf Download (408kB)
	PDF (BAB2) BAB II.pdf Restricted to Repository staff only Download (424kB) | Request a copy
	PDF (BAB3) BAB III.pdf Restricted to Repository staff only Download (527kB) | Request a copy
	PDF (BAB4) BAB IV.pdf Restricted to Repository staff only Download (682kB) | Request a copy
	PDF (BAB5) BAB V.pdf Restricted to Repository staff only Download (179kB) | Request a copy
	PDF (DAFTAR PUSTAKA) DAFTAR PUSTAKA.pdf Download (311kB)
	PDF (LAMPIRAN) LAMPIRAN.pdf Restricted to Repository staff only Download (1MB) | Request a copy
	PDF (Pernyataan Publikasi Ilmiah) SURAT PERNYATAAN PUBLIKASI ILMIAH.pdf Restricted to Repository staff only Download (713kB) | Request a copy
	PDF (Naskah Publikasi) NASKAH PUBLIKASI new.1.pdf Download (1MB)

Abstract

Aloe vera extracts (Aloe vera L.) can reduce LDL levels because it contains acemannan (glucomannan) active substances and cellulose. The active substances work by inhibiting cholesterol synthesis in the gut. The aim of this study was to study the effectiveness of Aloe vera L. extracts which can lower LDL levels in white male rat (Rattus norvegicus). This research is a laboratory experimental research with pre and post test method and control group design. The study was conducted on 25 white male rats (Rattus norvegicus) induced with high-fat diet for 14 days. Subjects were divided into 5 groups, namely: negative control group, positive control group (Cholestyramine 0.2g/200gBW/day), treatment group 1 (0.3 g/200 gBW/day), treatment group 2 (0.6 g/200 gBW/day) and treatment group 3 (1.2 g/200 gBW/day). Measurements of LDL cholesterol were performed on day 7, day 21, and day 35. Based on the result of post hoc statistic test, obtained (p <0,05) means there is significant differences between positive control group and treatment group 1, 2, and 3 showed by p ≤ 0,05. This indicated that aloe vera extracts dose 0,3 g/200 gBW/day, 0.6 g/200 gBW/day, and 1.2g/200 gBW/day had an effect to lower LDL levels compared to negative control (aquadest). The post hoc test results between treatment groups shows that the doses of 0.3 g/200gBW and 0.6 g/200gBW had comparable strength and the dose of 1.2 g/200gBW had the most optimum lowering effect. The administration of Aloe vera L. extracts dose I (0,3 g/200 gBW/day), II (0.6 g/200 gBW/day) and III (1.2 g/200gBW) can lower LDL level in rat (Rattus norvegicus).

Item Type:	Karya ilmiah (Skripsi)
Uncontrolled Keywords:	Aloe vera L., LDL, glukomanan, glukomanan dan selulosa
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Kedokteran > Kedokteran
Depositing User:	YUSTIKA QASTHARI PRIMAYANTI
Date Deposited:	08 Feb 2018 02:38
Last Modified:	08 Feb 2018 02:38
URI:	http://eprints.ums.ac.id/id/eprint/59664

Actions (login required)

View Item