Dewi, Vica Oktavia Citra and , Prof. DR. Dr. EM Sutrisna, M.Kes. (2018) Efek Ekstrak Ikan Gabus (Channa striata) Terhadap Kadar Kreatinin Pada Tikus Jantan Galur Wistar (Rattus norvegicus) Model Gagal Ginjal yang Diinduksi dengan Gentamisin. Skripsi thesis, Uniersitas Muhammadiyah Surakarta.
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Abstract
Background: Fish cork (Channa striata) has several content including zinc, albumin, high biologically valuable protein, ketogenic amino acid, and Branched Chain Amino Acids(BCAA). The content of ketogenic amino acids and Branched Chain Amino Acids(BCAA)has a function as an inhibitor of impaired renal function so that it can decrease creatinine levels. Objective: To investigate the effect of cork fish extract (Channa striata) on the reduction of blood creatinine level of Wistar male rats strain induced by gentamicin. Method: This research using pre and post test with control group design. The animals used on this test were 25 Wistar male white rats, divided into 5 treatment groups. Group 1 = negative control, group 2 = positive control was treated by ketosteryl at dose of 1.008 / 200 grBW, group 3 = cork fish extract 2 g / kgBW, group 4 = cork fish extract 4 g / kgBW cork fish, and group 5 = cork fish extract 8 g / kgBW. Result: One Way Annova test result got p value = 0,019 (p <0,05) which means that there is difference of effect of creatinine level reduction between the groups. Then followed by Post-Hoc analysis of LSD (Least Significant Diference) test between post-test group, K (+) with group K (-) value p = 0,002, K (-) with dose 1 value p = 0,165, K (-) with dose 2 values p = 0.016, K (-) with a dose of 3 values p = 0.011. The LSD (Least Significant Difference) test show that all doses show significant differences with p <0.05, except at K (-) with a dose of 1 with p> 0.05. Conclusion: the cork fish extract (Channa striata) use at dose of 2 g / kgBW, 4 g / kgBW, and 8 g / kgBW product blood creatinine level of gentamicin induced by Wistar strain rats.
| Item Type: | Karya ilmiah (Skripsi) |
|---|---|
| Uncontrolled Keywords: | cork fish extract (Channa striata), blood creatinine level. |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Kedokteran |
| Depositing User: | VICA OKTAVIA CITRA DEWI |
| Date Deposited: | 23 Jan 2018 03:11 |
| Last Modified: | 23 Jan 2018 03:11 |
| URI: | http://eprints.ums.ac.id/id/eprint/58427 |
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