Optimasi Formula Tablet Ekstrak Daun Yacon (Smallanthus Sonchifolius (Poepp. & Endl.) H. Robinson) Dengan Bahan Pengikat Pvp Dan Bahan Penghancur Natrium Alginat Menggunakan Metode Simplex Lattice Design

Purbaningrum, Wiedya and , Erindyah R.W.,Ph.D, Apt (2017) Optimasi Formula Tablet Ekstrak Daun Yacon (Smallanthus Sonchifolius (Poepp. & Endl.) H. Robinson) Dengan Bahan Pengikat Pvp Dan Bahan Penghancur Natrium Alginat Menggunakan Metode Simplex Lattice Design. Skripsi thesis, Universitas Muhammadiyah Surakarta.

[img] PDF (Naskah Publikasi)
NASKAH PUBLIKASI.pdf

Download (1MB)
[img] PDF (Halaman Depan)
HALAMAN DEPAN.pdf

Download (1MB)
[img] PDF (Bab I)
BAB I.pdf

Download (188kB)
[img] PDF (Bab II)
BAB II.pdf
Restricted to Repository staff only

Download (229kB)
[img] PDF (Bab III)
BAB III.pdf
Restricted to Repository staff only

Download (299kB)
[img] PDF (Bab IV)
BAB IV.pdf
Restricted to Repository staff only

Download (6kB)
[img] PDF (Daftar Pustaka)
DAFTAR PUSTAKA.pdf

Download (146kB)
[img] PDF (Lampiran)
LAMPIRAN.pdf
Restricted to Repository staff only

Download (1MB)
[img] PDF (Pernyataan Publikasi Ilmiah)
SURAT PERNYATAAN PUBLIKASI ILMIAH.pdf
Restricted to Repository staff only

Download (925kB)

Abstract

Yacon leaves (Smallanthus sonchifolius (Poepp. & Endl.) H. Robinson) contained caffeic, chlorogenic and ferulic acid. Previous study showed that these compounds may decrease blood glucose level. Formulating as tablet dosage could improve efficiency of yacon leaves application. This study was aimed to obtain an optimized formula of tablet using PVP as binder and natrium alginat as disintegrant. The study design was made by 5 formulas with various concentrations of PVP and sodium alginate (1%:7%; 2%:6%; 3%:5%; 4%:4%; 5%:3%). Parameter test was conducted on the flow rate, the angle of repose, tapped density, uniformity of weight, hardness, friability, and disintegration time. Optimization was designed by Design Expert 10.0.3.1 (trial) with simplex lattice design method which provides the optimum formula and predictive test results of physical properties of granules and tablets. Verification of the optimum formula then performed. The results of prediction and verification were analyzed using one sample t-test at 95% confidence level. The result showed that optimum formula of the tablet has obtained at a combination of 1% PVP and 7% sodium alginate. Statistical test on the prediction and verification data showed no significant differences in the angle of repose, tapped density, uniformity of weight, hardness, and disintegration time, so the data were valid. Significant differences showed in the flow rate and friability. However, the verification data on these parameters was eligible in the literature, so that the optimization results were valid.

Item Type: Karya ilmiah (Skripsi)
Uncontrolled Keywords: Yacon leaves (Smallanthus sonchifolius (Poepp. & Endl.) H. Robinson), PVP, sodium alginate, simplex lattice design
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Farmasi > Farmasi
Depositing User: WIEDYA PURBANINGRUM
Date Deposited: 03 Feb 2017 07:04
Last Modified: 03 Feb 2017 07:04
URI: http://eprints.ums.ac.id/id/eprint/48936

Actions (login required)

View Item View Item