Yazizah Jahwa, Jumiatul (2016) Uji Efek Analgesik Ekstrak Etanol 70% Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) Pada Mencit (Mus Musculus) Jantan Galur Swiss Yang Diinduksi Nyeri Asam Asetat Dengan Metode Geliat (Writhing Test). Skripsi thesis, Universitas Muhammadiyah Surakarta.
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Abstract
Background: Ginger rhizome plant (Curcuma xanthorrhiza Roxb) contains curcumin, xanthorrizhol and flavonoids. They are expected to have an analgesic effect. Objective: To determine the analgesic effect of the 70% ethanolic extract of ginger rhizome (Curcuma xanthorrhiza Roxb) and to determine the effective dose of the extract. Methods: This study used experimental laboratory methods With Post Test Only Control Group Design. The animals were 25 male Swiss strain mice 2-3 months old, weight 20-30 grams, and were divided into 5 groups: control group was treated by distilled water, Positive Control group was treated by aspirin 1.3 mg/20gBW, Group I, II and III treated by ginger rhizome extract a dose of 140 mg extract /KgBW, 280 mg/KgBW and 560 mg/KgBW respectively. Each group was stretched and the frequencies calculated using the writhing test. The data were analyzed with one-way ANOVA test followed by LSD (Least Significant Difference). Results: The ethanolic extract of ginger rhizome dose of 140 mg/KgBW, 280 mg/KgBW and 560 mg/KgBW had an analgesic effect with a mean frequency of writhing in a row was 179.40 times, 53.20 times and 22.20 times. Analysis of the data one-way ANOVA showed significantly different mean frequency of writhing in the of all groups p = 0.005 (p < 0.05). Conclusion: The 70% ethanolic extract of ginger rhizome (Curcuma xanthorrhiza Roxb) was dose of 140 mg/KgBW, 280 mg/KgBW and 560 mg/KgBW have analgesic effect in male mice Swiss strain. While the dose of 280 mg/KgBW and 560 mg/KgBW are effective analgesic dose.
| Item Type: | Karya ilmiah (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Ekstrak etanol, Rimpang temulawak (Curcuma xanthorrhiza Roxb), analgesik, mus musculus |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Kedokteran |
| Depositing User: | JUMIATUL YAZIZAH JAHWA |
| Date Deposited: | 15 Mar 2016 04:40 |
| Last Modified: | 15 Mar 2016 04:40 |
| URI: | http://eprints.ums.ac.id/id/eprint/42348 |
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