Jauhari, Rafika Hanifah and , Apt. Suprapto, S.Si., M.Sc (2024) Optimasi Tablet Lepas Lambat Teofilin Dengan Kombinasi Matriks Etilselulosa Dan Xanthan Gum Menggunakan Metode Simplex Lattice Design. Skripsi thesis, Universitas Muhammadiyah Surakarta.
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Abstract
Theophylline is one of the asthma drugs that has a narrow therapeutic index ranging between 5–20 g/ml and has a relatively short elimination half-life. The sustained release preparation of theophyllin is expected to be able to prolong the release of the drug, so that the level of the medication in the blood is more uniform and the effect of the medicine is in the therapeutic range. The study aims to find out the effects of the combination of ethyl cellulose (EC) and xanthane gum (XG) matrix on the physical properties, dissolution profiles, and obtaining the optimal formula of sustained release tablets of theophyllin. The sustained release tablet formula of theophylline was obtained using the Design Expert 13 program with the simplex lattice design (SLD) model EC (A) and XG (B) resulting in 7 formulas F1 (80:120), F2 (110:90), F3 (120:80), F4 (90:110), F5 (100:100), F6 (120:180), f7 (80:120). The evaluation of the granules covers the flow rate, the steady angle, and the compressibility index. The tablet evaluation covers weight consistency, content consistencies, hardness, fragility, and dissolving speed. The results of the physical properties of both granules and tablets indicate that all formulas have qualified. Xanthan gum is the most dominant component in enhancing flow properties, silent angle, compressibility percentage, weight uniformity, hardness, content uniformity and dissolving speed, while the more dominant EC component can increase tablet fragility and slow drug release from. A combination of EC of 100,46 mg and XG of 99.54 mg is an optimum formula combination recommended by the SLD method with a desirability value of 0.662.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | theophylline, sustained release, EC, XG, SLD |
| Subjects: | R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS02 Chemical Medicine |
| Divisions: | Fakultas Farmasi > Farmasi |
| Depositing User: | Unnamed user with username k100200058 |
| Date Deposited: | 11 Jan 2024 03:32 |
| Last Modified: | 11 Jan 2024 03:32 |
| URI: | http://eprints.ums.ac.id/id/eprint/119408 |
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