Literature Review : Sintesis Hidroksiapatit dari Bahan Alam sebagai Biomaterial

Rahmawati, Dita and , apt. Teguh Imanto, M.Farm. (2024) Literature Review : Sintesis Hidroksiapatit dari Bahan Alam sebagai Biomaterial. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Bone damage or bone defects are a significant global health problem that can cause loss of daily productivity and even death. The large number of cases of bone defects has led to an increase in demand for biomaterials or bone substitutes. Hydroxyapatite (HAp) is one of the most promising biomaterials for the treatment of bone defects. Synthetic hydroxyapatite risks being an expensive, complex, time-consuming method, producing hydroxyapatite with low biological performance with trace element deficiencies. Synthesis of hydroxyapatite using natural sources of calcium is an alternative. Several researchers have investigated the synthesis of hydroxyapatite from various sources, such as eggshells, snail shells, mammalian bones, etc. The purpose of this literature review is to provide information regarding the synthesis of hydroxyapatite using natural sources of calcium to assist in finding the best method with the resulting hydroxyapatite meeting the requirements for bone treatment applications. The article search method for compiling a literature review was carried out using the Boolean method on the Sciencedirect database of 2873 articles, then screening resulted in 38 articles. The article then creates a synthesis matrix to combine several elements to then obtain conclusions. The results of the Literature Review show that the choice of method and source of synthetic materials influences the particle size, crystallinity and stoichiometric composition of the resulting hydroxyapatite. Mechanochemical, hydrothermal, sol-gel and calcination methods tend to produce hydroxyapatite with small particle sizes and narrow particle size distributions. Calcination and hydrothermal methods tend to produce hydroxyapatite with higher crystallinity than other methods. The mechanochemical method can maintain stoichiometric composition and the hydrothermal method produces close to stoichiometric. The mechanochemical method is the simplest method with a shorter time. The natural material dolomite is free from any risk of infection and is safer to use than other material sources.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	hydroxyapatite, synthesis methods, natural materials, biomaterials
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Farmasi
Depositing User:	DITA RAHMAWATI
Date Deposited:	08 Jan 2024 03:22
Last Modified:	08 Jan 2024 03:22
URI:	http://eprints.ums.ac.id/id/eprint/119311

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