Systematic Review: Adverse Drug Reaction Dan Outcome Terapi Antituberculosis Pada Pasien Tb-Mdr

Tri Utami, Khoirunnisa and , .Apt. Hidayah Karuniawati, M.Sc., Ph.D (2023) Systematic Review: Adverse Drug Reaction Dan Outcome Terapi Antituberculosis Pada Pasien Tb-Mdr. Thesis thesis, Universitas Muhammadiyah Surakarta.

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Abstract

ABSTRACT Systematic Review: Adverse Drug Reaction and Outcome of Antituberculosis Therapy in MDR-TB Patients; TB-MDR is a condition where resistance occurs against two first-line drugs, rifampicin and isoniazid, with or without resistance to other antituberculosis drugs. Adverse Drug Reactions (ADRs) are the body's response to harmful or unwanted drugs occurring at the usual doses used in humans. ADRs often emerge during the treatment of MDR-TB patients. The aim of this study is to provide an overview of adverse drug reactions and the outcomes of antituberculosis therapy in MDR-TB patients. This Study adopts a systematic review design of cohort and cross-sectional studies. Articles used in this study were obtained from various databases, including PubMed and Google Scholar. and were published between 2011 and 2022. Article collection followed the PRISMA flow diagram. A total of 16 articles were identified, with 3 articles from Europe, 9 articles from Asia, and 4 articles from Africa. The results of ADR occurrence search showed that 1430 patients experienced at least one ADR finding, with a total of 3012 ADR findings. The conclusion drawn from this study is that ADRs resulting from MDR-TB therapy are experienced by patients, with the most common ADR occurrence being gastrointestinal disorders (nausea, vomiting, dyspepsia, acute abdomen) in 845 patients (35.82%). The desired outcome was achieved in 55.44% or 1730 patients, with a breakdown of 47.95% (1441 patients) having recovered and 9.62% (289 patients) having completed the treatment. Meanwhile, the undesired outcome constituted 42.49% or 1280 patients.

Item Type:	Thesis (Thesis)
Uncontrolled Keywords:	Keyword: Adverse Drugs Reactions, Antituberculosis therapy, Tuberculosis Multidrugs ressistant
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Pasca Sarjana > Magister Farmasi
Depositing User:	KHOIRUNNISA TRI UTAMI
Date Deposited:	23 Aug 2023 04:34
Last Modified:	23 Aug 2023 04:34
URI:	http://eprints.ums.ac.id/id/eprint/116916

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