Pengaruh Propoelixtm Terhadap Kadar Albumin Plasma Tikus Jantan Strain Wistar Albino Model Gagal Ginjal Kronik Induksi Acetaminophen

Aini, Nur and , Dr. Listiana Dharmawati S., M.Si (2021) Pengaruh Propoelixtm Terhadap Kadar Albumin Plasma Tikus Jantan Strain Wistar Albino Model Gagal Ginjal Kronik Induksi Acetaminophen. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Introduction : Chronic kidney disease decreased plasma albumin levels occur due to oxidative stress on the mitochondria of cells. The process of oxidative stress in experimental animals can be using acetaminophen. Oxidative stress can be controlled with PropoelixTM products, which contain antioxidants and anti-inflammatory so as to prevent increased albumin secretion in the urine. Objective : This study aimed to determine the effect of PropoelixTM on plasma albumin levels in male rats of wistar albino strain model of chronic kidney failure induced with acetaminophen. Methodology: This study used a true experimental design method with pre-test and post-test control group design assessments. The number of experimental animals was 28 male rats with inclusion criteria. The experimental animals were divided into 4 groups. Acetaminophen was given for 14 days and propoelixTM was given for 21 days. Albumin examination using the Spectrophotometer. Testing the data using the Annova test and post hoc turkey HSD. Results: The results showed that propoelixTM had an effect on plasma albumin levels of male wistar strain albino rats with p-value <0.01. PropoelixTM with a dose of 0.0216 g/ 200 g bw increased by 2.28 g. Meanwhile, with a dose of 0.0432g/ 200 g bw, albumin increased by 2.89 g. Conclusion : Given of propoelix™ either at a dose of 0.0216 g/200 g BW/day or at a dose of 0.0432 g/200 g BW/day had an effect on increasing plasma albumin levels in rats. PropoelixTM with a dose of 0.0432 g/ 200 gBW was more effective in increasing plasma albumin levels in rats.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Acetaminophen, Albumin, Gagal Ginjal Kronik, PropoelixTM Kepustakaan : 48 : 2003 – 2021
Subjects:	R Medicine > R Medicine (General) R Medicine > RN Nutrition R Medicine > RZ Other systems of medicine
Divisions:	Fakultas Ilmu Kesehatan > Gizi
Depositing User:	NUR AINI
Date Deposited:	12 Nov 2021 03:05
Last Modified:	01 Sep 2022 01:43
URI:	http://eprints.ums.ac.id/id/eprint/95436

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