Pengaruh Pemberian Ekstrak Buah Delima (Punica granatum L) Terhadap Gambaran Tubulus Seminiferus Mencit Jantan (Mus musculus L) Yang Diberikan Paparan Asap Rokok

Tias, Marti Eka Ning (2019) Pengaruh Pemberian Ekstrak Buah Delima (Punica granatum L) Terhadap Gambaran Tubulus Seminiferus Mencit Jantan (Mus musculus L) Yang Diberikan Paparan Asap Rokok. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Cigarette smoke is one of the biggest public health threats the toxic content of the source of free radicals and induce formation of Reactive Oxygen Species causing oxidative stress. Oxidative stress can cause testicular atrophy, atrophy of the seminiferous tubules, disruption of spermatogenesis in the seminiferous tubules which will reduce the quality of sperm, and an end to infertility. Pomegranate (Punica granatum L.) has polyphenols and flavonoids with antioxidant activity can reduce oxidative stress caused by free radicals and decrease in testicular tissue damage, thus preventing atrophy of the seminiferous tubules and prevent infertility. This study aims to determine the effectiveness and determine the effective dose of pomegranate extract in influencing seminiferous tubules histopatatologi picture of male mice. The method used in this study is an experimental method controlled post-test only group design. Subject of the study using 30 male mice Swiss strain were divided randomly into 5 groups. Consisting of normal group (given feed normal), negative controls (given 1 cigarette), the treatment group were given one cigarette and ekstak pomegranate with a dose of P1 350 mg/kg, P2 700 mg/kg, P3 1400 mg/kg. The treatment lasts for 35 days, on day 36 mice were terminated, and then be making preparations, then performed the histological assessment of the seminiferous tubules picture using jhonsen score. The results showed seminiferous tubules observational data normality test using with Shapiro-Wilk test showed the value of p> 0.05, so that said normal distribution of data. Levene test was done with a value of 0.216 (p> 0.05) indicates that the data has a homogeneous variant. Because the data is normal and homogeneous then analyzed using One way ANOVA, showed that the p value of 0.000. Furthermore, the use of LSD Post Hoc test. Negative control group results obtained provide a meaningful difference to the normal control group, the treatment 1,2 and 3. Meanwhile, between the treatment groups 1,2 and 3 there is a significant difference between the dose. The conclusion is the extract of pomegranate (Punica granatum L.).

Item Type:	Karya ilmiah (Skripsi)
Uncontrolled Keywords:	Ekstrak buah delima (Punica granatum L.), gambaran tubulus seminiferus, score jhonsen
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Fakultas Kedokteran
Depositing User:	MARTI EKA NING TIAS
Date Deposited:	27 Mar 2019 10:45
Last Modified:	27 Mar 2019 10:47
URI:	http://eprints.ums.ac.id/id/eprint/71839

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