Uji Efek Hipnotik-Sedatif Ekstrak Etanol 70 % Batang Jaka Tuwa (Scoparia Dulcis Linn) Terhadap Mencit Jantan Galur Swiss Webster

Sari, Dyah Ayu Purwita and , r. Safari Wahyu Jatmiko, M.Si. Med (2018) Uji Efek Hipnotik-Sedatif Ekstrak Etanol 70 % Batang Jaka Tuwa (Scoparia Dulcis Linn) Terhadap Mencit Jantan Galur Swiss Webster. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

THE HYPNOTIC EFFECT OF 70% ETHANOLIC EXTRACTS OF Scoparia dulcis Linn STEM ON SWISS WEBSTER MALEMICE Dyah Ayu Purwita Sari , Safari Wahyu Jatmiko Medical Faculty, Muhammadiyah SurakartaUniversity Background :Scoparia dulcis Linn contains flavonoids, tannins and saponins which have sedatif hypnotic effect. Objective: This study aims to determine the effect of 70% ethanolic extract of Scoparia dulcis Linn stem in giving hypnotic-sedatif effects on Swiss Webster male mice. Methods : This study is a laboratory experimental research with post test only control group design. The control group was used for comparison and evaluation. The objects of the study were 30 Swiss Webster male mice, weight 20-30 grams, 2-3 months old, divided into 5 groups with simple random sampling technique. Negatif control group (aquadest), positive control group (diazepam 1 mg/kgBW mice), treatment group dose I (50 mg/kgBW), dose II (100 mg/kgBW) and dose III (200 mg/kgBW). The sleep onset was calculated from the time treatment was given until the loss of righting reflex. The research was analyzed using post test only and one way ANOVA followed by Post Hoc Test. Results :The ethanol extract of 70% stem Jaka Tuwa dose III (200mg / kgWB) had sedative hypnotic effect that accelerated the onset of mice sleep with mean of 29.3 min (p <0,05). While at the dose I (50mg / kgWB) and dose II (100mg / kgWB) with an average of sleep onset of 93.5 minutes and 88 minutes, with p> 0.005 so it is not statistically significant. In one way ANOVA statistic test showed p value = 0.000 (p <0,05), so there was significant difference of onset of sleep of mice between group Conclusion :70% ethanol extract of Jaka Tuwa (Scoparia dulcis Linn) stem dose of 200mg / kgWB has a better sedative hypnotic effect than diazepam in Swiss Webster strain mice. ________________________________________ Keywords : Extracts of Scoparia dulcis Linn Stem, Sleep Disturbance,Hypnotic-Sedatif Effect.

Item Type:	Karya ilmiah (Skripsi)
Uncontrolled Keywords:	Ekstrak Batang Jaka Tuwa,Scoparia dulcis Linn, Gangguan Tidur, Efek Hipnotik Sedatif
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Divisions:	Fakultas Kedokteran > Kedokteran
Depositing User:	DYAH AYU PURWITA SARI
Date Deposited:	14 May 2018 02:46
Last Modified:	14 May 2018 02:46
URI:	http://eprints.ums.ac.id/id/eprint/62578

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