Uji Sitotoksik Ekstrak Etanol Daun Pepaya (Carica papaya) Terhadap Sel MCF-7 dan Sel T47D

Hariyanti, Siska and , Maryati, Ph.D., Apt. (2018) Uji Sitotoksik Ekstrak Etanol Daun Pepaya (Carica papaya) Terhadap Sel MCF-7 dan Sel T47D. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

One of the main causes of women’s mortality in Indonesia is breast cancer. Cancer treatments such as surgery, radiation, and systemic therapy (chemotherapy). However there are side effects on heart function, menstrual cycle disorders, and affect the immune system. The existence of the this problem, research require to find plants that have potential as an anticancer agent that is papaya (Carica papaya). Previous studies have suggested that papaya leaf is able to inhibit the growth of MCF-7 cells with an IC50 value of 9.73 μg /mL. The aim of this research is to know the cytotoxic effect of ethanol extract of papaya leaves against breast cancer cells MCF-7. The powder of simplicia was extracted with 96% ethanol. Cytotoxic test by MTT Assay. The concentration of papaya leaves ethanol extract used were 31.25; 62.5; 125; 250; and 500 μg/mL. Absorbation is read by ELISA reader at λ 595 nm. The result of cytotoxic test showed that the papaya leaves ethanol extract did not have cytotoxic activity against MCF-7 and T47D cells. Papaya leaves ethanol extract at 250 μg/mL was only able to inhibit MCF-7 growth by 8,43% and at 500 μg/mL concentration only inhibited T47D cell growth by 11,29%.

Item Type:	Karya ilmiah (Skripsi)
Uncontrolled Keywords:	Carica papaya, sel MCF-7, sel T47D, sitotoksik.
Subjects:	Q Science > QH Natural history > QH301 Biology
Divisions:	Fakultas Farmasi > Farmasi
Depositing User:	SISKA HARIYANTI
Date Deposited:	06 Feb 2018 03:19
Last Modified:	06 Feb 2018 03:19
URI:	http://eprints.ums.ac.id/id/eprint/59256

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