Pengaruh Ekstrak Etanol Herba Keladi Tikus (Typhonium flagelliforme L) Terhadap Sel Kanker Payudara MCF-7 Dan T47D

Rukhmia, Andi Istiqomah and , Maryati, Ph.D., Apt (2018) Pengaruh Ekstrak Etanol Herba Keladi Tikus (Typhonium flagelliforme L) Terhadap Sel Kanker Payudara MCF-7 Dan T47D. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Traditionally, the community has utilized rodent tuber (Typhonium flagelliforme) as breast cancer therapy. Previous research reported that the ethanol extract of rodent tuber have a cytotoxic effect on HeLa cells with IC50 of 30.19 µg/mL. The purpose of this study was to determine the cytotoxic effect ethanol extract of rodent tuber on breast cancer cells MCF-7 and T47D. The extraction of rodent tuber was performed used maceration method. To know the cytotoxic activity of rodent tuber was done by using MTT assay. The test solution concentrations series used were 500, 250, 125, 62.5 and 31.25 ppm. The absorbance was read on 594 nm use ELISA. The result of cytotoxic assay showed that ethanol extract of rodent tuber did not have cytotoxic activity against MCF-7 and T47D cells. At concentration 500 μg/mL ethanol extract of rodent tuber inhibited MCF-7 and T47D cells, respectively 29.18% and 6.72%.

Item Type:	Karya ilmiah (Skripsi)
Uncontrolled Keywords:	MCF-7.T47D. cytotoxic. Typhonium flagelliforme. MTT assay
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Farmasi
Depositing User:	Andi Istiqomah Rukhmia
Date Deposited:	06 Feb 2018 04:24
Last Modified:	06 Feb 2018 04:24
URI:	http://eprints.ums.ac.id/id/eprint/59252

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