Uji Aktivitas Sitotoksik Ekstrak Etanol Biji Mangga Golek, Madu, dan Arum Manis (Mangifera indica L.) terhadap Sel Kanker Payudara T47D

Hasanah, Aninda Faizatul and , Ratna Yuliani, M.Biotech.St. (2017) Uji Aktivitas Sitotoksik Ekstrak Etanol Biji Mangga Golek, Madu, dan Arum Manis (Mangifera indica L.) terhadap Sel Kanker Payudara T47D. Skripsi thesis, Universitas Muhammadiyah Surakarta.

	PDF (Naskah Publikasi) NASKAH PUBLIKASI_ANINDA FH_K100140044.pdf Download (870kB)
	PDF (Halaman Depan) HALAMAN DEPAN.pdf Download (585kB)
	PDF (Bab I) BAB I.pdf Download (111kB)
	PDF (Bab II) BAB II.pdf Restricted to Repository staff only Download (353kB) | Request a copy
	PDF (Bab III) BAB III.pdf Restricted to Repository staff only Download (641kB) | Request a copy
	PDF (Bab IV) BAB IV.pdf Restricted to Repository staff only Download (87kB) | Request a copy
	PDF (Daftar Pustaka) DAFTAR PUSTAKA.pdf Download (217kB)
	PDF (Lampiran) LAMPIRAN.pdf Restricted to Repository staff only Download (649kB) | Request a copy
	PDF (Pernyataan Publikasi Ilmiah) PERNYATAAN PUBLIKASI ILMIAH.pdf Restricted to Repository staff only Download (864kB) | Request a copy

Abstract

Breast cancer is a disease that mostly affects women. People tend to used natural products due to adverse drug reactions during chemotherapy. Seed kernel of mango (Mangifera indica L.) had been reported to have anticancer activity against T47D and MDA-MB-231 cell. The purpose of this research are to investigate the cytotoxic activity of seed kernel extract of mango golek, madu, and arum manis against breast cancer cells T47D and to identify the compounds in the extracts. The extraction was conducted by maceration method using 96% ethanol. The cytotoxic activity test was conducted by MTT assay method, with concentration series of extract of 400, 200,100, 50, and 25 μg / mL. Absorbance, obtained from MTT assay was read using ELISA reader at a wavelength 550 nm. Identification of compounds was conducted by Thin Layer Chromatography. The results showed that seed kernel of ethanol extract of mango golek, madu, and arum manis had no cytotoxic activity against breast cancer cells T47D. Percentage of living cells at concentration of 400 μg / mL of seed kernel extract of manggo golek, madu, and arum manis were 108,95 %; 112,16 %; 102,20 % respectively. The extracts contained tanin, phenolic, and flavonoid compounds.

Item Type:	Karya ilmiah (Skripsi)
Uncontrolled Keywords:	MTT assay, Mangifera indica L., T47D, cytotoxic
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Farmasi
Depositing User:	Aninda Faizatul Hasanah
Date Deposited:	30 Jan 2018 04:22
Last Modified:	30 Jan 2018 04:22
URI:	http://eprints.ums.ac.id/id/eprint/58559

Actions (login required)

View Item