DEWI , YULIA RATNA (2009) FORMULASI TABLET HISAP EKSTRAK DAUN SAGA (Abrus precatorius L.) DENGAN NATRIUM KARBOKSIMETILSELULOSA SEBAGAI BAHAN PENGIKAT MENGGUNAKAN METODE GRANULASI BASAH. Skripsi thesis, Universitas Muhammadiyah Surakarta.
![[img]](http://eprints.ums.ac.id/style/images/fileicons/application_pdf.png)
|
PDF
K100040163.pdf Download (108kB) |
|
|
PDF
K100040163.pdf Restricted to Repository staff only Download (2MB) |
Abstract
Ekstrak daun saga (Abrus precatorius L.) digunakan secara tradisional oleh masyarakat sebagai obat batuk dan sariawan. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh konsentrasi bahan pengikat natrium karboksimetilselulosa (CMC-Na) terhadap sifat fisik dan respon rasa tablet hisap ekstrak daun saga. Ekstrak daun saga dibuat secara maserasi dengan etanol 70% dan tablet hisap dibuat dengan metode granulasi basah. Tablet hisap dibuat menjadi empat formula dengan konsentrasi bahan pengikat yang berbeda pada formula I =1,5%, II=3%, III=4,5% dan IV=6%. Granul diuji waktu alir, sudut diam dan pengetapannya. Tablet hisap diuji sifat fisik meliputi keseragaman bobot, kekerasan, kerapuhan dan waktu melarut serta uji respon rasa dan uji KLT. Data dianalisis dengan menggunakan uji statistik Kolmogorov-Smirnov dilanjutkan dengan ANAVA (bila data terdistribusi normal). Hasil penelitian menunjukkan bahwa dengan meningkatnya konsentrasi CMC-Na menyebabkan semakin cepat waktu alir, semakin besar kekerasan dan semakin kecil kerapuhan tablet. Sudut diam dan pengetapan terkecil ditunjukkan oleh formula dengan konsentrasi CMC-Na 6%. Uji keseragaman bobot menunjukkan semua formula memenuhi persyaratan. Uji respon rasa tablet hisap pada formula I menunjukkan hasil persentasi responden paling tinggi yang menyatakan rasa enak . Uji KLT tablet hisap menunjukkan bahwa selama proses pembuatan tablet hisap, flavonoid dan saponin tidak mengalami kerusakan. Kata kunci : daun saga (Abrus precatorius L.), granulasi basah, natrium karboksimetilselulosa, tablet hisap FORMULATION OF SUCTION TABLET OF SAGA LEAF (Abrus precatorius L.) EXTRACT WITH NATRIUM CARBOXIMETHYL CELLULOSE AS BINDING AGENT BY WET GRANULATION METHOD ABSTRACT The extract of saga leaf (Abrus precatorius L.) traditionally used by people as cough and sprue medicine. This research aimed to know how influence concentration of binding agent of natrium carboximethyl cellulose (CMC-Na) to the physical characteristic and taste response of suction tablet of saga leaf extract. The extract of saga leaf is make by maseration with ethanol 70% and suction tablet is make by wet granulation method. The suction tablet divide into four formula with different concentration of binding agent on formula I = 1.5%, II = 3%, III = 4.5% and IV = 6%. The granule is tested its flowing time, stationary angle and bitting. The suction tablet is tested its physical characteristic including weigth homogeinity, hardness, britleness, and dissolving time and taste response test and TLC (thin layer chromatography) test. Then data obtained analyze using statistical test of Kolmogorof-Smirnov and following by ANAVA test (if distribution of data is normal). Result of the research show that by increasing concentration of CMC-Na caused increasing in flowing time, increasing in hardness and decreasing in britleness of tablet. The smallest stationary angle and bitting present on formula with 6% concentration of CMC-Na. Weigth homogeinity test show that all formula is significant. Taste response test of suction tablet on formula I show the highest percentage of respondent who explain a good taste. The TLC test of suction tablet show that through process of make a suction tablet, flavonoid and saponin have not damage.
| Item Type: | Karya ilmiah (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Saga leaf (Abrus precatorius L.), wet granulation, natrium carboximethyl cellulose, suction tablet |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Farmasi |
| Depositing User: | Mrs. Gatiningsih Gatiningsih |
| Date Deposited: | 01 Jul 2009 08:11 |
| Last Modified: | 16 Nov 2010 15:17 |
| URI: | http://eprints.ums.ac.id/id/eprint/3343 |
Actions (login required)
 |
View Item |
