Desnasya, Fadhila Illyas and , Azis Saifudin, S.Farm., Apt., M.Sc., Ph.D (2025) Efek Antivirus Fraksi Etil Asetat Ekstrak Metanol Biji Srikaya (Annona Squamosa L.) Terhadap Virus Newcastle Disease. Skripsi thesis, Universitas Muhammadiyah Surakarta.
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Abstract
The seeds of srikaya (Annona squamosa L.) contain alkaloids, saponins, flavonoids, tannins, polyphenolics, and RIP (Ribosome-Inactiviting Protein) that have potential antiviral activity. We tested the inhibition of ethyl acetate fraction of methanol extract of srikaya (Annona squamosa L.) seeds against newcastle disease virus as a model for viruses with genomes in the form of negative single-stranded RNA such as SARS-CoV2. Using embryonated chicken eggs as a virus growth medium and hemagglutination test, we found that the ethyl acetate fraction of methanol extract of cicada seeds, even at levels as low as 0.01 µg/mL had an inhibition of 99.21%. The positive control using a commercial antiviral drug (favipiravir) only inhibited 66.14%. The KLT separation of ethyl acetate fraction of methanol extract of srikaya seed indicated the dominance of alkaloid compounds. The results of this study indicate that alkaloid compounds obtained from the ethyl acetate fraction of methanol extract of srikaya seeds have antiviral effects against single-stranded negative RNA viruses.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Annona squamosa, Embryoated chicken eggs, Newcastle disease. |
| Subjects: | R Medicine > Pharmacy and materia medica R Medicine > Pharmacy and materia medica > Ekstrak Tumbuhan Obat |
| Divisions: | Fakultas Farmasi > S1 Farmasi |
| Depositing User: | FADHILA ILLYAS DESNASYA |
| Date Deposited: | 07 Jan 2025 01:56 |
| Last Modified: | 07 Jan 2025 01:56 |
| URI: | http://eprints.ums.ac.id/id/eprint/129664 |
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