Pengaruh Propoelix Terhadap Kadar Asam Urat Pada Tikus Jantan Strain Wistar Albino Model Gagal Ginjal Kronik

Cindy Erasi Awaliza, Ruth and , dr. Listiana Dharmawati Suryaningrum, S.Ked., M.Si (2021) Pengaruh Propoelix Terhadap Kadar Asam Urat Pada Tikus Jantan Strain Wistar Albino Model Gagal Ginjal Kronik. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Chronic kidney disease is a associated with oxidative stress due to increased of ROS that can increase blood uric acid levels due to a decrease in the ability of the kidneys to excrete uric acid. Propoelix™ contains CAPE as an antioxidant component that can inhibit the process of oxidative stress so that it can reduce blood uric acid. This research method is a true experimental design with pre-test and post-test control group design. The reasearch subjects were 28 male rats of the wistar albino strain according to the inclusion and exclusion criteria. Subjects were divided into 2 control groups and 2 treatment groups, each group consisted of 7 rats. K1 (positive control group/non CKD), K2 (negative control group/CKD), K3 (Propoelix™ treatment group at 0.0216 g/200 g BW), and K4 (Propoelix™ treatment group at 0.0432 g/200 g BW). Measurement of uric acid levels using the enzymatic photometric test method TBHBA (2,4,6 – tribromo – 3 – hydroxybenzoic acid) in pre and post-treatment. There was a significant decrease (p<0.01) in the blood uric acid levels of rats given Propoelix™. The Propoelix™ treatment group at a dose of 0.0216 g/200 g BW decreased uric acid levels by 49.56% while the Propoelix™ treatment group at a dose of 0.0432 g/200 g BW experienced a 68.23% decrease in uric acid levels. So, provision of Propoelix ™ doses of 0.0216 g/200 g BW and 0.0432 g/200 g BW has an effect on reducing blood uric acid levels in chronic kidney disease rats.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Asam Urat, Gagal Ginjal Kronik, Propoelix™
Subjects:	H Social Sciences > H Social Sciences (General) R Medicine > R Medicine (General) R Medicine > RN Nutrition R Medicine > RZ Other systems of medicine
Divisions:	Fakultas Ilmu Kesehatan > Gizi
Depositing User:	RUTH CINDY ERASI AWALIZA
Date Deposited:	18 Nov 2021 03:17
Last Modified:	01 Sep 2022 01:58
URI:	http://eprints.ums.ac.id/id/eprint/95907

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