Aktivitas Sitotoksik Ekstrak Etanol Buah Pare (Momordica charantia L.) Terhadap Sel Kanker MCF-7 dan T47D

Kharima, Fitri Nur and , Ratna Yuliani, M.Biotech.st. (2019) Aktivitas Sitotoksik Ekstrak Etanol Buah Pare (Momordica charantia L.) Terhadap Sel Kanker MCF-7 dan T47D. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Breast cancer is a type of cancer with the second highest prevalence of cancer after cervical cancer. Some cancer treatments have side effects. Bitter melon fruit (Momordica charantia L.) contains compounds that have anticancer activity. This study aims to determine cytotoxic activity of ethanolic extract of bitter melon fruit on MCF-7 and T47D cancer cells and identify natural compounds in the ethanolic extract of bitter melon fruit. Bitter melon was extracted using maceration method with 96% ethanol. The method used to determine the cytotoxic activity of bitter melon extract was the MTT assay method with the extract concentrations series of 50, 100, 200, 400, and 800 µg/mL. The compounds in the extract were analyzed using thin layer chromatography (TLC). Cytotoxic tests result showed that the ethanolic extract of bitter melon fruit had IC50 values of 408,823 µg/mL on MCF-7 and 155,459 µg/mL cells in T47D cells. The results of TLC showed that the ethanolic extract of bitter melon fruit contains terpenoids, flavonoids, steroid saponins, phenolics, and alkaloids. Ethanolic extract of bitter melon fruit has no potential cytotoxic activity to be developed.

Item Type:	Karya ilmiah (Skripsi)
Uncontrolled Keywords:	Buah pare, Momordica charantia, MTT, Sel MCF-7, Sel T47D, KLT.
Subjects:	Q Science > QH Natural history > QH301 Biology
Divisions:	Fakultas Farmasi > Farmasi
Depositing User:	FITRI NUR KHARIMA
Date Deposited:	11 Feb 2019 07:52
Last Modified:	11 Feb 2019 07:52
URI:	http://eprints.ums.ac.id/id/eprint/70705

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