Uji Efektivitas Ekstrak Lidah Buaya (Aloe Vera L.) Terhadap Penurunan Kolesterol Total Pada Tikus (Rattus Norvegicus) Putih Jantan Hiperkolesterolemia

Satriyani, Oktein and , Dr. Devi Usdiana Rosyidah,M.Sc (2018) Uji Efektivitas Ekstrak Lidah Buaya (Aloe Vera L.) Terhadap Penurunan Kolesterol Total Pada Tikus (Rattus Norvegicus) Putih Jantan Hiperkolesterolemia. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Coronary heart disease is one of the biggest causes of death. Coronary heart disease is caused by the buildup of cholesterol in blood vessels. Aloe vera (Aloe vera L.) has many benefit on which one of them can lower blood cholesterol levels. The purpose of this study is to study the effective dose of aloe vera extracts (Aloe vera L.) which decreases rat (Rattus norvegicus) blood cholesterol level. The method used in this research was an experimental research with pre and post test method and control group design. Aloe vera extracts (Aloe vera L.) used was obtained through maceration method. Aloe vera extracts (Aloe vera L.) was extracted using ethanol 70%. Doses of aloe vera extract used were 0,3 gr/200 grBW, 0,6 gr/200 grBW, 1,2 gr/200 grBW. The positive control used in this study was cholestyramine. The rats were divided into 5 treatment groups, namely the positive control group given cholestyramine, the aquadest negative group, the first treatment group with the first dose, the second treatment group with the second dose, and the third treatment group with the third dose. Based on the result normality and homogenity test results indicate that the data distribution is normal and homogeneous. Statistical test results using one way ANOVA obtained p <0,05, means there are significant differences between each group. LSD test results showed significant differences between groups with different test times. It can be concluded that Aloe vera L. extracts could decrease total blood cholesterol level in white hypercholesterolemic male rat (Rattus norvegicus).

Item Type:	Karya ilmiah (Skripsi)
Uncontrolled Keywords:	hypercholesterolemic, aloe vera, Aloe vera L., total cholesterol
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	Fakultas Kedokteran > Kedokteran
Depositing User:	OKTEIN SATRIYANI
Date Deposited:	14 Feb 2018 01:52
Last Modified:	14 Feb 2018 01:52
URI:	http://eprints.ums.ac.id/id/eprint/60358

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