Optimasi Formula Tablet Fast Disintegrating Na-Diklofenak Dengan Flowlac 90, Starlac, Dan Tablettose 80 Sebagai Pengisi Dengan Metode Simplex Lattice Design

Arum, Hanindya Puspita and , Suprapto, M.Sc.,Apt (2018) Optimasi Formula Tablet Fast Disintegrating Na-Diklofenak Dengan Flowlac 90, Starlac, Dan Tablettose 80 Sebagai Pengisi Dengan Metode Simplex Lattice Design. Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Diclofenac sodium is a non steroidal anti inflammatory drug with analgesic, antipyretic, and anti inflammatory properties which undergoes extensive first pass metabolism resulting a terminal half life of 1 to 2 hours. Additives material used in this formulation of diclofenac sodium fast disintegrating tablet were flowlac 90, starlac, and tablettose 80 which are multifunctional. The aim of this research was to know the effects of adding flowlac 90, starlac, and tablettose 80 as diluents to the tablet properties and to find optimum formula of diclofenac sodium fast disintegrating tablets. In this study, fast disintegrating tablets of diclofenac sodium using 3 different concentrations of each diluents by using simplex lattice design method and then analyzed using design expert 11. The pre compression parameters like angle of repose, bulk density, tapped density, carr’s index, and housner ratio were tested. The post compression parameters like weight variation, hardness, friability, wetting time, and in vitro disintegration time were evaluated. The results showed that the combination of flowlac 90, starlac, and tablettose 80 as diluents could affect the physical properties of the tablet that is the weight variation was good, the tablet hardness was increased, the friability tablet was increased, wetting time and disintegration tablet were increased. The results was then analyzed using design expert 11 with simplex lattice design method and concluded that formula with concentration of flowlac 90, starlac, and tablettose 80 (0,497:0,026:0,476) has optimum point.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: diclofenac sodium, flowlac 90, starlac, tablettose 80, simplex lattice design, fast disintegrating tablet.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi
Depositing User: HANINDYA PUSPITA ARUM
Date Deposited: 07 Feb 2018 02:05
Last Modified: 07 Feb 2018 02:05
URI: http://eprints.ums.ac.id/id/eprint/59466

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