Uji Efek Analgesik Ekstrak Etanol 70% Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) Pada Mencit (Mus Musculus) Jantan Galur Swiss Yang Diinduksi Nyeri Asam Asetat Dengan Metode Geliat (Writhing Test)

Yazizah Jahwa, Jumiatul (2016) Uji Efek Analgesik Ekstrak Etanol 70% Rimpang Temulawak (Curcuma Xanthorrhiza Roxb) Pada Mencit (Mus Musculus) Jantan Galur Swiss Yang Diinduksi Nyeri Asam Asetat Dengan Metode Geliat (Writhing Test). Skripsi thesis, Universitas Muhammadiyah Surakarta.

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Abstract

Background: Ginger rhizome plant (Curcuma xanthorrhiza Roxb) contains curcumin, xanthorrizhol and flavonoids. They are expected to have an analgesic effect. Objective: To determine the analgesic effect of the 70% ethanolic extract of ginger rhizome (Curcuma xanthorrhiza Roxb) and to determine the effective dose of the extract. Methods: This study used experimental laboratory methods With Post Test Only Control Group Design. The animals were 25 male Swiss strain mice 2-3 months old, weight 20-30 grams, and were divided into 5 groups: control group was treated by distilled water, Positive Control group was treated by aspirin 1.3 mg/20gBW, Group I, II and III treated by ginger rhizome extract a dose of 140 mg extract /KgBW, 280 mg/KgBW and 560 mg/KgBW respectively. Each group was stretched and the frequencies calculated using the writhing test. The data were analyzed with one-way ANOVA test followed by LSD (Least Significant Difference). Results: The ethanolic extract of ginger rhizome dose of 140 mg/KgBW, 280 mg/KgBW and 560 mg/KgBW had an analgesic effect with a mean frequency of writhing in a row was 179.40 times, 53.20 times and 22.20 times. Analysis of the data one-way ANOVA showed significantly different mean frequency of writhing in the of all groups p = 0.005 (p < 0.05). Conclusion: The 70% ethanolic extract of ginger rhizome (Curcuma xanthorrhiza Roxb) was dose of 140 mg/KgBW, 280 mg/KgBW and 560 mg/KgBW have analgesic effect in male mice Swiss strain. While the dose of 280 mg/KgBW and 560 mg/KgBW are effective analgesic dose.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Ekstrak etanol, Rimpang temulawak (Curcuma xanthorrhiza Roxb), analgesik, mus musculus
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Kedokteran > Kedokteran
Depositing User: JUMIATUL YAZIZAH JAHWA
Date Deposited: 15 Mar 2016 04:40
Last Modified: 15 Mar 2016 04:40
URI: http://eprints.ums.ac.id/id/eprint/42348

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